Hutcheson Lab Members Bolded

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Cardiac Research

Iqbal, F., Schlotter, F., Becker-Greene, D., Lupieri, A., Goettsch, C., Hutcheson, J. D., Rogers, M. A., Itoh, S., Halu, A., Lee, L. H., Blaser, M. C., Mlynarchik, A. K., Hagita, S., Kuraoka, S., Chen, H. Y., Engert, J. C., Passos, L. S. A., Jha, P. K., Osborn, E. A., Jaffer, F. A., and Aikawa, E. “Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity”, European Heart Journal. 2023 Jan 20:ehac818. 

Hsu, C. D., Tchir, A., Mirza, A., Chaparro, D., Herrera, R. E., Hutcheson, J. D., and Ramaswamy, S. “Valve Endothelial Cell Exposure to High Levels of Flow Oscillations Exacerbates Valve Interstitial Cell Calcification”, Bioengineering (Basel, Switzerland). Aug 16; 9(8):393.

Nasim, S., Pandey, P., Kanashiro-Takeuchi, R. M., He, J., Hutcheson, J. D., and Kos, L. “Pigmentation Affects Elastic Fiber Patterning and Biomechanical Behavior of the Murine Aortic Valve”, Frontiers in Cardiovascular Medicine. Dec 10; 8:754560.

Tong, L., and Hutcheson, J. D. “A surface-based calibration approach to enable dynamic and accurate quantification of colorimetric assay systems”, Analytical Methods: Advancing Methods and Applications. 2021 Sep 30; 30;13(37):4290-4297.

Hutcheson, J. D., Schlotter, F., Creager, M. D., Li, X., Pham, T., Vyas, P., Higashi, H., Body, S. C., Aikawa, M., Singh, S. A., Kos, L., and Aikawa, E. “Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets”, Frontiers in Cardiovascular Medicine. 2021 Jun 22; 8:678401.

Büttner, P., Feistner, L., Lurz, P., Thiele, H., Hutcheson, J. D., and Schlotter, F.  “Dissecting Calcific Aortic Valve Disease-The Role, Etiology, and Drivers of Valvular Fibrosis”, Frontiers in Cardiovascular Medicine. 2021 May 10; 8:660797.

Schlotter, F., de Freitas, R. C. C., Rogers, M. A., Blaser, M. C., Wu, P. J., Higashi, H., Halu, A., Iqbal, F., Andraski, A. B., Rodia, C. N., Kuraoka, S., Wen, J. R., Creager, M., Pham, T., Hutcheson, J. D., Body, S. C., Kohan, A. B., Sacks, F. M., Aikawa, M., Singh, S. A., and Aikawa, E. “ApoC-III is a novel inducer of calcification in human aortic valves”, The Journal of Biological Chemistry. 2021 Jan 6; 296:100193.

Heuschkel, M. A., Skenteris, N. T., Hutcheson, J. D., van der Valk, D. D., Bremer, J., Goody, P., Hjortnaes, J., Jansen, F., Bouten, C. V. C., van den Bogaerdt, A., Matic, L., Marx, N., and Goettsch, C. “Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits”, Cells. 2020 Sep 24; 9(10):2164.

Hsu C.D. , Hutcheson J.D., and Ramaswamy S. “Oscillatory fluid-induced mechanobiology in heart valves with parallels to the vasculature”,  Vascular Biology (Bristol, England). 2020 Feb 17; 2(1):R59-R71.

Chaparro, D., Dargam, V., Alvarez, P., Yeung, J., Saytashev, I., Bustillo, J., Loganathan, A., Ramella-Roman, J., Agarwal, A. and Hutcheson, J., “A Method to Quantify Tensile Biaxial Properties of Mouse Aortic Valve Leaflets”, Journal of Biomechanical Engineering. 2020 Aug 31; 142(10):100801.

Hsu, C. P. D., Hutcheson, J. D., & Ramaswamy, S. “Oscillatory fluid-induced mechanobiology in heart valves with parallels to the vasculature”, Vascular Biology. 2020 Mar 16; 2(1):R59-R71.

Scholotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman Jg, Aikawa M, Singh DA, Aikawa E. “Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease”, Circulation. 2019 Jul 24; 138(4):377-3.

K Yabusaki, JD Hutcheson, P Vyas, S Bertazzo, SC Body, M Aikawa, E Aikawa, “Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development”, Frontiers in Cardiovascular Medicine, Nov 4; 3:44, 2017.

J Hjortnaes, C Goettsch, JD Hutcheson, G Camci-Unal, L Lax, K Scherer, FJ Schoen, J Kluin, A Khademhosseini, E Aikawa, “Simulating Early Calcific Aortic Valve Disease within a 3D Heart Valve-like Construct: A Role for Myofibroblast Differentiation”, Journal of Molecular and Cellular Cardiology, 94:13-20, 2016.

J Hjortnaes, K Shapero, C Goettsch, JD Hutcheson, J Keegan, J Kluin, JE Mayer, J Bischoff, E Aikawa, “Valvular Interstitial Cells Suppress Calcification of Valvular Endothelial Cells”, Atherosclerosis, 242(1): 251-260, 2015. Link to Publication

JD Hutcheson, E Aikawa, WD Merryman, “Potential drug targets for calcific aortic valve disease”, Nature Reviews Cardiology, 11(4): 218-31, 2014. Link to Publication

JD Hutcheson, J Chen, MK Sewell-Loftin, LM Ryzhova, CI Fisher, YR Su, WD Merryman, “Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts”, Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33(1): 114-20, 2013. Link to Publication

JD Hutcheson, L Ryzhova, V Setola, and WD Merryman, “5-HT2B antagonism arrests non-canonical TGF-β1-induced myofibroblast differentiation”, Journal of  Molecular and Cellular Cardiology, 53(5): 707-714, 2012.

JD Hutcheson, R Venkataraman, FJ Baudenbacher, and WD Merryman, “Intracellular Ca2+ accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts”, Journal of Biomechanics, 45(5): 888-894, 2012. Link to Publication

JD Hutcheson, V Setola, BL Roth, and WD Merryman, “Serotonin Receptors and Heart Valve Disease—It Was Meant 2B”, Phamacology & Therapeutics, 132(2): 146-157, 2011. Link to Publication

Vascular Research

Bakhshian Nik, A., Ng, H. H., Ashbrook, S. K., Sun, P., Iacoviello, F., Shearing, P. R., Bertazzo, S., Mero, D., Khomtchouk, B. B., & Hutcheson, J. D. “Epidermal Growth Factor Receptor Inhibition Prevents Vascular Calcifying Extracellular Vesicle Biogenesis”, American journal of physiology. Heart and circulatory physiology. 2023 Feb 24; 10.1152/ajpheart.00280.2022.

Ashbrook S.K., Valentin Cabrera A.M., Shaver M., and Hutcheson J.D. “Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models”, Journal of Visualized Experiments: Jove. 2023 Jan 27; (191).

Laverde, E. E., Polyzos, A. A., Tsegay, P. P., Shaver, M., Hutcheson, J. D., Balakrishnan, L., McMurray, C. T., and Liu, Y. “Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair”, Genes. 2022 Dec 29;14(1):98.

Krohn, J. B., Aikawa, E., Aikawa, M., Hutcheson, J. D., Sahoo, S., and Fish, J. E. “Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.  Frontiers in Cardiovascular Medicine. 2022 Nov 8; 9:1077124.

Bakhshian Nik, A., Ng, H. H., Garcia Russo, M., Iacoviello, F., Shearing, P. R., Bertazzo, S., and Hutcheson, J. D. “The Time-Dependent Role of Bisphosphonates on Atherosclerotic Plaque Calcification”, Journal of Cardiovascular Development and Disease. 2022 May 25; 9(6):168.

Iwata, H., Osborn, E. A., Ughi, G. J., Murakami, K., Goettsch, C., Hutcheson, J. D., Mauskapf, A., Mattson, P. C., Libby, P., Singh, S. A., Matamalas, J., Aikawa, E., Tearney, G. J., Aikawa, M., and Jaffer, F. A. “Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging”, Journal of the American Heart Association. 2021 Oct 19; 10(20):e020834.

Ruiz, J. L., Hutcheson, J. D., Cardoso, L., Bakhshian Nik, A., Condado de Abreu, A., Pham, T., Buffolo, F., Busatto, S., Federici, S., Ridolfi, A., Aikawa, M., Bertazzo, S., Bergese, P., Weinbaum, S., and Aikawa, E. “Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model”, Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 6; 118(14):e1811725118.

Rogers, M. A., Hutcheson, J. D., Okui, T., Goettsch, C., Singh, S. A., Halu, A., Schlotter, F., Higashi, H., Wang, L., Whelan, M. C., Mlynarchik, A. K., Daugherty, A., Nomura, M., Aikawa, M., and Aikawa, E. “Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion”, Cardiovascular Research. 2021 Sep 28; 117(11):2340-2353.

Boonya-Ananta, T., Rodriguez, A. J., Ajmal, A., Du Le, V. N., Hansen, A. K., Hutcheson, J. D., and Ramella-Roman, J. C. “Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI)”, Scientific Reports. 2021 Jan 28; 11(1):2570.

Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. “18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images”, Circ Cadiovasc Imaging. 2019 Jan; 12(1)

Hutcheson JD, Aikawa E. “Extracellular Vesicles in Cardiovascular Homeostasis and Disease”, Curr Opin Cardiol. 2018 May; 33(3):290-297.

Pokhrel R, Gerstman BS, Hutcheson JD, Chapagain PP. “In Silico Investigations of Calcium Phosphate Mineralization in Extracellular Vesicles”, J Phys Chem B. 2018 Apr 12; 122(14):3782-3789.

Bakhshian Nik AHutcheson JD, Aikawa E, “Extracellular Vesicles As Mediators of Cardiovascular Calcification”, Frontiers in Cardiovascular Medicine. 2017 Dec 11;4:78.

C Goettsch, H Iwata, JD Hutcheson, CJ O’Donnell, R Chapurlat, NR Cook, M Aikawa, P Szulc, E Aikawa, “Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men”, Arteriosclerosis, Thrombosis, and Vascular Biology, 37(5): 1005-1011, 2017.

JD Hutcheson, MC Blaser, E Aikawa, “Giving Calcification Its Due: Recognition of a Diverse Disease A First Attempt to Standardize the Field”, Circulation Research, 120(2):270-273, 2017.

Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E, “Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress”, Circulation Research, 121(3): 220-233, 2017.

R Krammann, C Goettsch, J Wongboonsin, H Iwata, RK Schneider, C Kuppe, N Kaesler, M Chang-Panesso, F Machado, S Gratwohl, C Vemuri, K Madhurima, JD Hutcheson, S Jain, E Aikawa, BD Humpreys, “Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease”, Cell Stem Cell, 19(5):628-642, 2016. Link to Publication

C Goettsch*, JD Hutcheson*, S Hagita*, M Rogers, MD Creager, T Pham, J Choi, AK Mlynarchik, MF Kjolby, M Aikawa, E Aikawa, “A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification”, Atherosclerosis, 251:109-18, 2016. *Equal Contribution Link to Publication

C O’Rourke, G Shelton, JD Hutcheson, MF Burke, T Martyn, HR Shakartzi, MD Buswell, RE Tainsh, B Yu, DK Rhee, C Wu, M Derwall, ES Buys, PB Yu, KD Bloch, E Aikawa, DB Bloch, R Malhotra, “Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation”, Journal of Visualized Experiments, May 31;(111), 2016.

JD West, EJ Carrier, NC Bloodworth, AK Schroer, P Chen, LM Ryzhova, S Gladson, S Shay, JD Hutcheson, WD Merryman, “Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension”, PLoS One, 11(2):e0148657, 2016.

J Krohn, JD Hutcheson*, E Martinez-Martinez, WS Irvin, S Bertazzo, CVC Bouten, MP Bendeck, E Aikawa*, “Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via TGF-β Signaling”, Arteriosclerosis, Thrombosis, and Vascular Biology, 36(3):525-33, 2016. *Co-corresponding authors Link to Publication

JL Ruiz, Weinbaum S, Aikawa, E, JD Hutcheson, “Zooming in on the genesis of atherosclerotic plaque microcalcifications”, Journal of Physiology, 594(11):2915-27, 2016.

JD Hutcheson, C Goettsch, S Bertazzo, N Maldonado, JL Ruiz, W Goh, K Yabusaki, T Faits, C Bouten, P Libby,  M Aikawa, S Weinbaum, E Aikawa, “High-resolution microscopic visualization of vascular calcification genesis, growth, and association with collagen in atherosclerotic plaques”, Nature Materials, 15(3):335-43, 2016.

C Goettsch, JD Hutcheson,  M Aikawa, A Nykjaer, M Kjolby, M Rogers, T Michel, M Shibasaki, DJ Rader, P Libby, SA Singh, E Aikawa, “Sortilin mediates vascular calcification via its recruitment into extracellular vesicles”, Journal of Clinical Investigation, 126(4):1323-36, 2016. Link to Publication

JD Hutcheson, C Goettsch, MA Rogers, E Aikawa, “Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach”, Invited Review, Seminars in Cell and Developmental Biology, 46:68-77, 2015. Link to Publication

J Ruiz, JD Hutcheson, E Aikawa, “Cardiovascular Calcification: Current Controversies and Novel Concepts”, Invited Review, Cardiovascular Pathology, 10(7), 2015. Link to Publication

JD Hutcheson, C Goettsch, T Pham, M Aikawa, SA Singh, E Aikawa, “Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol”, Journal of Extracellular Vesicles, Dec 5;3:25129, 2014. Link to Publication

JD Hutcheson, N Maldonado, E Aikawa, “Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability”, Current Opinion in Lipidology, 25(5):327-32, 2014. Link to Publication

C Goettsch, JD Hutcheson, and E Aikawa, “MicroRNA in cardiovascular calcification: Focus on targets and extracellular vesicle delivery mechanisms”, Circulation Research, 112(7): 1073-84, 2013. Link to Publication